The Hannah Montana actress's garnet gown was a far cry from the skimpy latex bikini she wore on stage with Robin Thicke back in 2013.
Miley's designer frock hung off her shoulders elegantly while ruched tulle covered her arms and cascaded down into a full, floor-length skirt.
The Wrecking Ball singer's ensemble teamed a strapless bodice with slim cigarette pants, adding a unique touch with a textured shawl.
She teamed the stylish singlet with towering heels that featured a chunky silver heel and almost-invisible strap across her tows.
The starlet also shared a brief moment with Alicia Keys, who wowed in all black.
She kissed Miley's hand tenderly as she made her way to the stage.
Miley carried a long-stemmed white rose in honor of Time's Up while keeping the rest of her accessories to a minimum.
Miley teamed up with fashionisto Zac Posen, who was responsible for both of the starlet's looks that evening.
The designer looked dapper in grey velvet while Cyrus planted a kiss on his cheek.
The The Climb singer was all smiles as she headed backstage after the duet.
She continued to show off her couture, spinning to display the design's fantastic skirt.